My only must-see show on TV nowadays, the one that I get irritated if I miss, is Pushing Daisies. Yup. I'm a big ol' softie.
I hestitated to mention that one because I knew it didn't fit well the rest of the recommendations...and I doubted that many other people would enjoy it. My wife and I watch that show regularly (although we never worry about missing it because we don't have cable...we just watch it online when the network puts it out).
Combine Wonderfalls (also on Netflix, created by the same person - Bryan Fuller, and the main character of Pushing Daisies is also in this) with quirky humor and a voice-over by the same person that did the voice-over for Hitchhikers Guide to the Galaxy (oddly enough, it's also the same girl as well), and you have Pushing Daisies.
My wife and I have debated how long it will take the network to cancel this show. We love the show, but suspect that most people won't...and Bryan Fuller's shows have a habit of getting cancelled...they are just too unique and have an intelligent wit that most viewers probably can't appreciate.
Jengenritz, just in case you're interested, Bryan Fuller also created Wonderfalls and Dead Like Me (both also on Netflix).
Dead Like Me - they weren't consistent with some of the plot (particularly the rules of the reapers), but we still loved the series. You have to get past the first several episodes in season 1 (we almost abandoned the series early). There is one female actor who leaves the show....after that point, she is replaced by Daisy Adare (character's name)...AFTER that, the show starts to improve. By the end of it, you love the characters and love the show.
Wonderfalls - we didn't enjoy it as much as Dead Like Me (whose deadpan humor we missed sorely), but it was still a good show (actually, some of it's quirky humor reminds me of Pushing Daisies).
-Fathead apparently watches too much TV